Sökning: "tigecycline"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet tigecycline.

  1. 1. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

    Författare :Marius Linkevičius; Dan I. Andersson; Linus Sandegren; Patrice Courvalin; Uppsala universitet; []
    Nyckelord :Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

    Sammanfattning : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. LÄS MER

  3. 2. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis

    Författare :Magnus von Seth; Lipscey Miklós; Jan Sjölin; Mats Eriksson; Jukka Takala; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; animal models; microdialysis; endotoxin; Escherichia coli; tigecycline; doxycycline; albumins; capillary leak syndrome; lactic acid; oxygen delivery; multiple organ failure; mitochondria; tumor necrosis factor alpha; interleukin-6; cyanides; ouabain; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. LÄS MER

  4. 3. Antibiotic resistance in Gram-negative bacilli : with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae

    Författare :Owe Källman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Objectives: The objectives of this thesis were to study mechanisms conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum beta-lactamase) producing isolates of Escherichia coli and Klebsiella pneumoniae, as well as the presence of co-resistance to other antibiotics in the K. pneumoniae isolates. LÄS MER

  5. 4. Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae : Antibiotic consumption, Detection and Resistance Epidemiology

    Författare :Åse Östholm Balkhed; Lennart Nilsson; Håkan Hanberger; Hans-Jurg Monstein; Anita Hällgren; Mats Kalin; Linköpings universitet; []
    Nyckelord :Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae; Antibiotic consumption; Detection Methods; Multiplex PCR; Resistance Epidemiology; Multi-resistance; E. coli; ESBL; fecal carriage; faecal carriage; travel;

    Sammanfattning : ESBL-producing Enterobacteriaceae are emerging worldwide and they are frequently multi-drug resistant, thus limiting treatment options for infections caused by these pathogens.The overall aim of the thesis was to investigate ESBL-producing Enterobacteriaceae in a Swedish county. LÄS MER

  7. 5. Antibiotic resistance in the pan-genome of E. coli

    Författare :Jennifer Jagdmann; Hervé Nicoloff; Dan I. Andersson; Alex O´Neill; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; pan-genome; genetic diversity; plasmids; Mikrobiologi; Microbiology;

    Sammanfattning : The pan-genome of a species is made up of all gene families that can be included in any individual isolate of the species. Escherichia coli (E. coli) has an open pan-genome including at least 128000 gene families, while only about half of the genes found in each individual isolate are common to all isolates. LÄS MER