Sökning: "monozygotic"

Visar resultat 16 - 20 av 64 avhandlingar innehållade ordet monozygotic.

  1. 16. Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder

    Författare :Viktoria Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Previously identified cerebrospinal fluid (CSF) biomarkers were studied in 37 twins with schizophrenia or bipolar disorder to determine their genetic and environmental properties. Further, comorbidities and sibling risks were investigated in patients with schizophrenia (n=22,781), bipolar disorder (n=30,761) and depression (n=172,479) in relation to multiple sclerosis (MS) (n=16,467) in a nationwide cohort. LÄS MER

  3. 17. Identification of abnormally expressed genes in skeletal muscle contributing to insulin resistance and type 2 diabetes

    Författare :Xudong Huang; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; gene expression; high-fat intake; RT-PCR; mitochondrial genes; cathepsin L; Shc; IRS-2; IRS-1; GS; cDNA differential display; Insulin resistance; type 2 diabetes; sekretion; diabetologi;

    Sammanfattning : The metabolic defects of insulin resistance and type 2 diabetes can result from changes in gene expression and protein functions due to genetic and environmental influences. The aim of this study was to identify abnormally expressed genes associated with insulin resistance or type 2 diabetes, and further to test whether possible defects are inherited or acquired. LÄS MER

  4. 18. Studies of congenital genetic aberrations behind childhood leukemia

    Författare :Benedicte Bang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, initiators of BCP-ALL. LÄS MER

  5. 19. Epidemiological studies on diverticular disease of the colon

    Författare :Johan Granlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Objective: The aims of this thesis were to evaluate if there is an association between diverticular disease and colorectal cancer (Paper I), to assess any genetic contribution to the occurrence of diverticular disease (Paper II), determine how common hospitalization and surgery for diverticular disease are in measures of admission rates, incidence rates and lifetime risk (Paper II), and to estimate mortality in diverticulitis patients, needing hospital care (Paper IV). Methods: Swedish national registries were cross-linked through individual personal identification numbers. LÄS MER

  7. 20. Perinuclear Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease

    Författare :Ping Yang; Stefan Lindgren; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Antineutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies which are specific for granulocyte antigens. By indirect immunofluorescence (llF) on ethanol-fixed neutrophils, ANCAs can be divided into two types: a cytoplasmic staining pattern (C-ANCA) or a perinuclear staining pattern (P-ANCA). LÄS MER