Sökning: "mesangial cell"

Visar resultat 11 - 15 av 18 avhandlingar innehållade orden mesangial cell.

  1. 11. Identification of genes and pathways involved in the development and progression of glomerular diseases

    Författare :Dina Dabaghie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) affects millions of people worldwide and is characterized by a reduction in glomerular filtration rate and albuminuria resulting in a gradual loss of kidney function. The high prevalence of the disease, along with the limited treatment options available, makes it a major burden to the health care systems around the world. LÄS MER

  3. 12. Conditional targeting of the PDGF-B gene

    Författare :Maria Enge; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene targeting; Cre loxP; PDGF; pericytes; diabetic retinopathy; brain injury; neurons;

    Sammanfattning : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. LÄS MER

  4. 13. Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides

    Författare :Mark Lal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; diabetes; Na; K-ATPase; ouabain; oxidative stress;

    Sammanfattning : The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current study we have investigated the intracellular signalling cascades activated downstream of two separate stimuli: the diabetic milieu and the cardiac glycoside, ouabain. LÄS MER

  5. 14. Role of new podocyte-associated proteins in the renal ultrafiltration barrier

    Författare :Angelina Schwarz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. LÄS MER

  7. 15. Studies on biological treatment and biomarkers in systemic lupus erythematosus : longterm effects, risk factors and predictors of response

    Författare :Francesca Faustini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which several immune mechanisms are involved in a complex interplay. B-cells are considered to be a major player in the pathophysiology of the disease, and the advent of B-cell depletion therapy (BCDT), has brought much promise. LÄS MER