Sökning: "mesangial cell"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden mesangial cell.

  1. 6. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER

  3. 7. Functional analysis of genes in the developing zebrafish pronephros and vasculature

    Författare :Lwaki Ebarasi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During glomerulogenesis, the recruitment and assembly of visceral epithelial cells (podocytes), endothelial capillary cells, and smooth muscle pericytes (mesangial cells) result in the formation of the glomerular tuft. The mature glomerulus functions by passage of plasma under hemodynamic pressure across a filter, the glomerular filtration barrier, and the integrity of the barrier is crucial for proper function. LÄS MER

  4. 8. Expression profiling of blood vessels in pericyte deficiency and diabetes

    Författare :Jenny Norlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The kidney glomerulus is essential for the filtration of waste products from the blood into the urine and in controlling the volume and composition of body fluids. Injury to the glomerulus can lead to altered glomerular filtration rate, proteinuria, thickening of the glomerular basement membrane (GBM) and accumulation of mesangial cell matrix. LÄS MER

  5. 9. Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels

    Författare :Liang Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition called diabetic nephropathy (DN). LÄS MER

  7. 10. The role of glycoproteins in glomerular pathophysiology

    Författare :Alina Khramova; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteoglycans; Extracellular matrix; IgA nephropathy; Diabetic kidney disease;

    Sammanfattning : Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no specific treatments available and mechanisms behind the onset and progression of CKD are still not fully investigated. LÄS MER