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Visar resultat 21 - 25 av 64 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Adverse drug effects on glucose and lipid metabolism: is human adipose tissue of importance?

   Författare :Assel Sarsenbayeva; Jan Eriksson; Mikael Rydén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human adipose tissue; metabolic adverse effects; SGAs; statins; glucocorticoids; glucose uptake; lipolysis; myofibroblasts; fibrosis; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

   Sammanfattning : Many pharmacological agents that are widely prescribed in clinical practice have adverse metabolic effects, such as hyperglycaemia, insulin resistance, and diabetes. Among such drugs are antipsychotics, prescribed for treatment of schizophrenia; statins, which inhibit cholesterol synthesis and prevent cardiovascular events; finally, potent anti-inflammatory agents, glucocorticoids. LÄS MER

3. 22. Studies of Eosinophil Cationic Protein (ECP) in vivo and in vitro : Impact of Genetic and Posttranslational Modifications

   Författare :Jenny Eriksson; Per Venge; Agneta Trulson; Ester Boix; Uppsala universitet; []
   Nyckelord :Biomedicine; Eosinophil granulocyte; granular protein; ECP; gene polymorphism; cytotoxicity; SELDI-TOF MS; glycosylation; molecular and functional heterogeneity; fibrosis; Biomedicin;

   Sammanfattning : Eosinophil granulocytes are tissue dwelling leukocytes that are implicated in host defence, particularly against helminthic parasites; they also participate in most inflammatory disorders. Although eosinophils have important roles in host defence mechanisms, their actions can also be harmful to the host as in the allergic inflammation where lung epithelium is destructed due to the release of toxic granule proteins. LÄS MER

4. 23. MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis

   Författare :Mara Caputo; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; STE20-type kinases; MST3; MST4; lipid droplets; antisense oligonucleotide treatment; fibrosis;

   Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, NAFLD is currently the most common etiology of chronic liver disease in Western countries and its prevalence continues to grow. LÄS MER

5. 24. Quantitative magnetic resonance in diffuse liver and neurological disease

   Författare :Olof Dahlqvist Leinhard; Linköpings universitet; []
   Nyckelord :Mapping--methods; Choline--analysis; Liver diseases--diagnosis; Magnetic resonance imaging--methods; Magnetic resonance spectroscopy--methods; Multiple sclerosis--diagnosis; Multiple sclerosis--metabolism; Nerve fibers; myelinated--metabolism; MEDICINE; MEDICIN;

   Sammanfattning : Magnetic resonance (MR) has become one of the most important diagnostic tools in modern medicine. It provides superior soft tissue contrast compared to other imaging modalities, it is extremely flexible as it can be used to image all parts of the body, and it is considered to be safe for patients. LÄS MER

7. 25. Understanding the genetic architecture of fatty liver disease

   Författare :Jamialahmadi Oveis; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; Polygenic risk score; Genomewide association studies; Mendelian Randomization;

   Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. LÄS MER