Sökning: "lipid polymorphism"

Visar resultat 16 - 20 av 36 avhandlingar innehållade orden lipid polymorphism.

  1. 16. Inflammation and matrix degrading proteases in coronary artery disease

    Författare :Ann Samnegård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myocardial infarction; matrix metalloproteinases; inflammation; polymorphism; haplotype; gender; cytokines;

    Sammanfattning : Coronary artery disease (CAD) is a major cause of morbidity and death in the world today. The underlying process, atherosclerosis, is caused by lipid accumulation and inflammatory processes within the intimal layer of the vessel wall. LÄS MER

  3. 17. Estrogen and liver X receptors in human disease

    Författare :Maria Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; Liver X Receptor; polymorphism; Bulimia Nervosa; SNP; BMI; obesity; expression levels; T2D.;

    Sammanfattning : The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated several pathophysiological conditions in which the NRs are involved. LÄS MER

  4. 18. Fatty acid transport proteins : candidate genes for the insulin resistance syndrome

    Författare :Karl Gertow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fatty acid transport protein; fatty acid; triglyceride; lipoprotein; obesity; insulin resistance; adipose tissue; polymorphism; association study; gene expression;

    Sammanfattning : The insulin resistance syndrome is characterised by insulin resistance, obesity, hypertension, and a typical dyslipidaemia, predisposing to diabetes and cardiovascular disease. Metabolic disturbances of the insulin resistance syndrome include dysregulation of fatty acid (FA) homeostasis, for which adipose tissue serves a critical function. LÄS MER

  5. 19. The metabolic syndrome : studies on thrifty genes

    Författare :Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

    Sammanfattning : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. LÄS MER

  7. 20. Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction

    Författare :Anna Aminoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipids including triglycerides, cholesterol, cholesterol esters and fatty acids are important sources for energy production, act as building blocks for intracellular compartments, are involved in numerous biological pathways and may act as signal molecules. Lipids are transported in blood as lipoproteins between organs, where they are immediately used in cellular processes or stored as cytosolic lipid droplets. LÄS MER