Sökning: "PPAR"

Visar resultat 1 - 5 av 33 avhandlingar innehållade ordet PPAR.

  1. 1. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

    Författare :Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
    Nyckelord :Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

    Sammanfattning : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. LÄS MER

  3. 2. PPAR delta : its role in cholesterol metabolism

    Författare :Josefin Skogsberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Peroxisome proliferator activated receptor delta; polymorphism; association studies; LDL-cholesterol; coronary heart disease; LDL receptor; gene expression;

    Sammanfattning : Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that regulate several biological processes, many of which are crucial for energy homeostasis. Three different isotypes have been identified; PPARalpha, PPARdelta and PPARgamma that are encoded by different genes and show different expression patterns and functions. LÄS MER

  4. 3. Type 2 Diabetes in a Defined Population The Skaraborg Hypertension and Diabetes Project

    Författare :Carl Johan Östgren; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; HOMA; primary care; all-cause mortality; Pro12Ala; PPAR-gamma; survival; insulin resistance; beta-cell function; type 2 diabetes; hypertension; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : To examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). LÄS MER

  5. 4. STAT5 expression and regulation in mammary epithelial cells

    Författare :Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

    Sammanfattning : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). LÄS MER

  7. 5. Endothelial cell interactions with neutrophils : studies of adhesion and effects of lipoxygenase metabolites and antirheumatic drugs

    Författare :Mikael Heimbürger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion; auranofin; endothelium; gold sodium thiomalate; leukotrienes; lipoxins; neutrophils; PPAR; prednisolone;

    Sammanfattning : Inflammation is a process of vital importance in the defence and elimination of microorganisms as well as in the repair of the damaged tissue. However, inadequate or excessive inflammation leads to inflammatory diseases such as rheumatoid arthritis. LÄS MER