Sökning: "lck"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet lck.

  1. 1. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands

    Författare :Michael Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CD8 T cells; APL; CTLs; non-responsiveness; AICD; lck; lipid rafts; partial agonism; TCR activation.;

    Sammanfattning : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). LÄS MER

  3. 2. Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3

    Författare :Alissa Marhäll; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; AML; FLT3;

    Sammanfattning : Among adults, acute myeloid leukemia (AML) is the second most frequent type of leukemia. In spite of recent improvements in the treatment of this disease, a majority of patients develop drug resistance, leading to poor overall survival. One of the factors behind this is mutations in the tyrosine kinase receptor (FLT3). LÄS MER

  4. 3. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors

    Författare :Neivis Tormo-Badia; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. LÄS MER

  5. 4. Regulatory aspects of innate immune responses

    Författare :Ahmed El Marghani; Per-Erik Olsson; Peter Kjellén; Muhammad Zafarullah; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Innate immunity; TOM1L1; inflammatory responses; Biology; Biologi;

    Sammanfattning : Activation of innate immunity is regulated by a variety of signaling molecules within the immune cells. The present thesis was aimed to improve our understanding of innate signaling mechanism and their possible use as bio-indicators of exposure and disease. LÄS MER

  7. 5. Biochemical and Structural Studies on the Adaptor Protein p130Cas

    Författare :Fariborz Nasertorabi; Kathryn R Ely; Lars Liljas; Jyrki Heino; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Integrin signaling; p130Cas; X-ray Crystallography; NMR Spectroscopy; Protein phosphorylation; BCAR-1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. LÄS MER