Sökning: "lars block"

Visar resultat 6 - 10 av 32 avhandlingar innehållade orden lars block.

1. 6. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

   Författare :Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

   Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER

3. 7. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

   Författare :Lars Johannesen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. LÄS MER

4. 8. SNP based strategies to study candidate genes for Alzheimer’s disease

   Författare :Lars Feuk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer s disease; complex disease; SNP; polymorphism; association study; genotyping; DASH;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is a genetically heterogeneous disease characterized by progressive cognitive decline and memory impairment. The rare familial form of AD is caused by three different genes called APP, PSEN1 and PSEN2. LÄS MER

5. 9. Breaking the chains : A technological and industrial transformation beyond papermaking: Technology management of incumbents

   Författare :Michael Novotny; Staffan Laestadius; Lars Coenen; KTH; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Technological and industrial transformation; development block; incumbents; pulp and paper industries; wood-based biorefinery; diverging innovations of non-assembled products; Teknologisk och industriell omvandling; utvecklingsblock; etablerade företag och industrier; massa- och pappersindustrin; vedbaserade bioraffinaderier; divergerande innovationer av icke-sammansatta produkter.; Industriell ekonomi och organisation; Industrial Engineering and Management;

   Sammanfattning : In recent years, the necessity and opportunity for transforming pulp and paper mills into integrative units for large-scale output of biochemicals, biomaterials, and biofuels have come up in discussions of industrial renewal in the Northern hemisphere (mainly in Canada, Sweden and Finland). This transformation is related to technology shifts as well as changing business models based on new bioproducts due to profoundly new market conditions. LÄS MER

7. 10. Neuromuscular function in the normal and inflamed colon. An experimental study in rat

   Författare :Lars Börjesson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; dextran sulphate sodium; DMPP; enteric nervous system; McN-A-343; nitric oxide; non-adrenergic; rat; second messenger; smooth muscle; VIP;

   Sammanfattning : Neuromuscular function of the longitudinal muscle layer of distal colon was investigated in segments from normal rats and from rats with colitis induced by dextran sulphate sodium (DSS) at 3% for 3 or 7 days or 5% for 7 days. The study was performed in vitro, on spontaneous tone, or after precontraction. LÄS MER