Sökning: "intravital imaging"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden intravital imaging.

  1. 1. A close-up on neutrophils : Visualizing the mechanisms of their in vivo recruitment and function

    Författare :Sara Massena; Mia Phillipson; Randall S. Jonhson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; chemokine; chemotactic gradient; citrullination; hypoxia; inflammation; intraluminal crawling; intravital imaging; PAD enzymes; permeability; proangiogenic; proinflammatory;

    Sammanfattning : A successful immune response depends on prompt and sufficient recruitment of leukocytes from the circulation to infected or injured sites. Mobilization of leukocytes to hypoxic tissues is vital for angiogenesis, i.e. the formation of new blood vessels from preexisting vasculature, and thus crucial for tissue growth and regeneration. LÄS MER

  3. 2. In vivo imaging of leukocyte-endothelium interactions in septic lung injury

    Författare :Jonas Roller; Kirurgi; []
    Nyckelord :Sepsis; Acute lung injury; Leukocyte recruitment; Intravital fluorescence microscopy;

    Sammanfattning : Excessive accumulation of leukocytes in the lung represents a key feature in the development of an acute lung injury (ALI). Numerous studies demonstrated that leukocyte rolling is a compulsory precondition for the firm adhesion in organs. However, it seems that the recruitment process of leukocytes in the lung is more complex. LÄS MER

  4. 3. Tissue microbiology : an integrated approach for intravital studies of host-pathogen interactions

    Författare :Ferdinand Xiankeng Choong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A bacteria infection in the living host is the summation of a myriad of interactions. Reductionistic and sacrificial experiment models cannot replicate this complexity. The Tissue Microbiology approach overcomes this by allowing the live host and pathogen to control all facets of the infection model. LÄS MER

  5. 4. Deciphering cell motility and spatial sensing of intestinal cell types using an ex vivo intestinal model

    Författare :Anna Webb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intestine is a highly organized tissue with two distinct regions: the crypt and the villus. When stem cells divide at the crypt bottom, half of their progeny migrates upwards towards the villus, where they differentiate into various cell types, including the abundant absorptive enterocytes. LÄS MER

  7. 5. VEGF-B in islet of langerhans : role in vascular signaling and lipid handling

    Författare :Frank Chenfei Ning; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies demonstrated the beneficial/therapeutic effects of reducing VEGF-B signaling systemically. LÄS MER