Sökning: "proangiogenic"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet proangiogenic.

  1. 1. A close-up on neutrophils : Visualizing the mechanisms of their in vivo recruitment and function

    Författare :Sara Massena; Mia Phillipson; Randall S. Jonhson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; chemokine; chemotactic gradient; citrullination; hypoxia; inflammation; intraluminal crawling; intravital imaging; PAD enzymes; permeability; proangiogenic; proinflammatory;

    Sammanfattning : A successful immune response depends on prompt and sufficient recruitment of leukocytes from the circulation to infected or injured sites. Mobilization of leukocytes to hypoxic tissues is vital for angiogenesis, i.e. the formation of new blood vessels from preexisting vasculature, and thus crucial for tissue growth and regeneration. LÄS MER

  3. 2. Directing Angiogenesis : Cellular Responses to Gradients in vitro

    Författare :Irmeli Barkefors; Johan Kreuger; Lena Kjellén; Pär Gerwins; Ferdinand Le Noble; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Endothelial cell; Cell migration; Chemotaxis; Gradients; Microfluidics; VEGFA; VEGFR2; Exocyst; Exocytosis; Cell and molecular biology; Cell- och molekylärbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. LÄS MER

  4. 3. C-Kit as an Oncogenic Tyrosine Kinase - Regulation and Dysregulation of Signaling Pathways

    Författare :Malin Pedersen; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. LÄS MER

  5. 4. Mechanism of pathological angiogenesis in adipose tissue and tumor

    Författare :Yuan Xue; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Angiogenesis is critical for both malignant diseases, such as cancer, and non-malignant diseases, such as obesity and metabolic disorders. Majority of tissues and organs are highly vascularized. The malfunctions of tissue microenvironment are always accompanied with or dependent on the alterations of vasculature. LÄS MER

  7. 5. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets

    Författare :Gustaf Christoffersson; Mia Phillipson; Kristian Pietras; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; pancreatic islet transplantation; islets of Langerhans; diabetes mellitus; leukocytes; neutrophils; macrophages; pericytes; MMP-9; VEGF-A; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. LÄS MER