Sökning: "intrathecal antibody"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden intrathecal antibody.

1. 1. Studies of the Biology of Intrathecal Treatment in Progressive MS

   Författare :Joakim Bergman; Anders Svenningsson; A. Tommy Bergenheim; Jonathan D. Gilthorpe; Joachim Burman; Magnus Andersson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progressive Multiple Sclerosis; intrathecal treatment; Ommaya reservoir; anti-CD20 therapy; microdialysis; cerebrospinal fluid; CNS compartments; Progressiv Multipel Skleros; intratekal behandling; Ommaya reservoar; anti-CD20 terapi; mikrodialys; ryggmärgsvätska; sektioner i centrala nervsystemet; Neurology; neurologi;

   Sammanfattning : Background: Multiple Sclerosis (MS) is a chronic, inflammatory, autoimmune disease, affecting the central nervous system (CNS). About 85% of afflicted present with a relapsing-remitting form of the disease (RRMS), for which a breakthrough in treatment was made in 2008 with rituximab, an antibody directed towards CD20, a surface antigen on B-cells. LÄS MER

3. 2. Studies on the humoral immune response in nervous system infections with special reference of facial palsy and lyme borreliosis

   Författare :Magnus Roberg; Göran Stiernstedt; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : This thesis is mainly based on studies of the humoral immune response in subjects with neurological infections with special reference to facial palsy and Lyme borreliosis. Cerebrospinal fluid and/or serum samples from a total of 281 patients were investigated. LÄS MER

4. 3. Tick-borne encephalitis : on pathogenesis and prognosis

   Författare :Göran Günther; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Human; tick-borne encephalitis; viral; meningo-encephalitis; cerebrospinal fluid; PCR; cytokines; immunoglobulin; SPECT; technetium-99m-HMPAO;

   Sammanfattning : The general aim of the five studies presented in this thesis was to investigate the clinical outcome and prognosis and factors of importance for the pathogenesis of TBE compared to other aseptic meningo-encephalitis. In a prospective study 149 patients presenting with clinical symptoms of acute viral meningo-encephalitis between June 1991 and December 1993 were included. LÄS MER

5. 4. In search of lost disease : Clinical, qualitative and imaging studies to investigate long-term effects of autologous haematopoietic stem cell transplantation for multiple sclerosis

   Författare :Andreas Tolf; Joachim Burman; Anne-Marie Landtblom; Tobias Granberg; Laura Airas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; Neurologi;

   Sammanfattning : With the introduction of autologous haematopoietic stem cell transplantation (AHSCT) for the treatment of multiple sclerosis (MS), there are now individuals living without experiencing disease activity of MS. Are they cured? There is a need for terminology to describe the state of these individuals. LÄS MER

7. 5. Tick-borne encephalitis : prognosis, immunization and virus strain characterization

   Författare :Mats Haglund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :tick-borne encephalitis; tick-borne encephalitis virus; human; clinical picture; sequelae; virus characterization; phylogeny; vaccination; neutralization;

   Sammanfattning : The aims were to investigate the morbidity associated with tick-borne encephalitis (TBE) both in the acute phase and at long-term follow-up, to develop a rapid neutralization test for confirmation of TBEV-specific antibody response and to study the serological response after TBE-vaccination and, finally, to characterize Swedish human TBEV isolates. The morbidity was studied in one retrospective follow-up study of consecutive TBE-patients, treated during a 10-year period (Paper 1) and in one prospective study of TBE-patients with aseptic meningoencephalitis of non-TBE etiology as a reference group (Paper II). LÄS MER