Sökning: "lars block"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden lars block.

  1. 1. Baltzar von Platen, Thomas Telford och Göta kanal : Entreprenörskap och tekniköverföring i brytningstid

    Detta är en avhandling från Stockholm : Stehag : Symposion graduale

    Författare :Lars Strömbäck; Linköpings universitet.; Linköpings universitet.; [1993]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; canal construction; development block; entrepreneur; the Gotha Canal; Göta kanal; Motala verkstad; von Platen; technology transfer; Telford; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : The Gotha Canal was built during 1810-1832 and it was the biggest building enterprise that Sweden up to that time had undertaken. To a poor and preindustrialised country the whole project was economically as well as technically a tremendous challenge. LÄS MER

  2. 2. In Vitro – In Vivo Correlation of Injectable Lipid Formulations

    Detta är en avhandling från Hospital Pharmacy, University Hospital, Malmö, Sweden and Department of Food Technology, Engineering and Nutrition, Lund University, Sweden

    Författare :Lars Söderberg; Lunds universitet.; Lund University.; [2008]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EC 50; erythrocyte; human plasma; lipid injectable formulation; IVIVC; fatty acid; in vitro release; Peripheral nerve block; neurolytic; structure-activity;

    Sammanfattning : In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. LÄS MER

  3. 3. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Lars Ottosson; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER

  4. 4. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Lars Johannesen; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. LÄS MER

  5. 5. SNP based strategies to study candidate genes for Alzheimer's disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Center for Genomics Research

    Författare :Lars Feuk; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; complex disease; SNP; polymorphism; association study; genotyping; DASH;

    Sammanfattning : Alzheimer's disease (AD) is the most common form of dementia in the elderly. It is a genetically heterogeneous disease characterized by progressive cognitive decline and memory impairment. The rare familial form of AD is caused by three different genes called APP, PSEN1 and PSEN2. LÄS MER