Sökning: "in vitro reprogramming"
Visar resultat 11 - 15 av 36 avhandlingar innehållade orden in vitro reprogramming.
11. Mechanisms Underlying the Specification of Definitive Hematopoiesis
Sammanfattning : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. LÄS MER
12. Deciphering microglia plasticity in glioma
Sammanfattning : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. LÄS MER
13. Impact of targeting MYC in metabolic reprogramming and differentiation of cancer
Sammanfattning : Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor genes and oncogenes that initiate cancer development, are responsible directly and indirectly of the changes in major cellular energy production processes, including glycolysis, glutaminolysis, and lipid metabolism. LÄS MER
14. Coiled coil cytoskeleton in cell architecture and osmotic stress response in Streptomyces
Sammanfattning : Coiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. LÄS MER
15. Altered cell metabolism and migration in nasopharyngeal carcinoma
Sammanfattning : Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, environmental factors, and lifestyle factors. NPC has the highest metastasis rate among all head and neck cancers. LÄS MER