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1. 1. Mechanisms Underlying the Specification of Definitive Hematopoiesis

   Författare :Rita Alves; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GATA2; mitotic bookmarking; HSC; transcription factors; reprogramming;

   Sammanfattning : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. LÄS MER