Sökning: "immunoglobulin genes"

Visar resultat 26 - 30 av 98 avhandlingar innehållade orden immunoglobulin genes.

  1. 26. Molecular studies of the humoral immune response in Hyalophora cecropia : structure, function and transcriptional regulation of three classes of immunoresponsive genes

    Författare :Shao-Cong Sun; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Insects have an efficient humoral immune system, an important part of which is constituted by the antibacterial proteins, produced upon bacterial infection or wounding. In this thesis, the molecular mechanism of this immune response was investigated in the giant silkmoth Hyalophora cecropia, where a set of bacteriainducible proteins (immune proteins) had previously been characterized. LÄS MER

  3. 27. Conquering complexity : successful strategies for finding disease genes in multiple sclerosis

    Författare :Kerstin Imrell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a complex disease; at an intra-individual level several contributory factors cause the disease; at an inter-individual level different factors contribute to the disease. The aim of the thesis project was to reduce this complexity by focusing of subsets of patients that were likely to share to a higher extent contributory causes and to identify in these subsets genes conferring susceptibility. LÄS MER

  4. 28. Regulation of Immunoglobulin Isotype Switching and of the Germinal Center Response

    Författare :Minghui He; Eva Severinson; Jayanta Chaudhuri; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : After stimulation, B cells can undergo two types of genetic alteration in their immunoglobulin (Ig) genes: somatic hypermutation and class switch recombination (CSR), both of which are initiated by activation-induced cytidine deaminase (AID).Although class switching requires cell proliferation, the mechanism is partly unknown. LÄS MER

  5. 29. Regulation of the murine immunoglobulin GL gamma-1 and epsilon promoters

    Författare :Lena Ström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system takes advantage of different genetic alterations to amplify its diversity. First at early stages of B cell differentiation when the antigen (ag) receptors are assembled from different gene segments. LÄS MER

  7. 30. Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity

    Författare :Martin Johansson; Solbritt Rantapää Dahlqvist; Ingrid Lundberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; RA; oestrogen; renal disorder; ESR1; PDCD1; PTPN22; association; severity; Rheumatology; Reumatologi; Medicine; medicin;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with systemic manifestations characterized by auto-antibodies directed against different parts of the cell nucleus including DNA, histones and ribosomes. The systemic inflammation can cause damage to multiple organs, e.g., kidneys, skin, heart, lungs and the nervous system. LÄS MER