Sökning: "PDCD1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet PDCD1.

  1. 1. Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity

    Författare :Martin Johansson; Solbritt Rantapää Dahlqvist; Ingrid Lundberg; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; RA; oestrogen; renal disorder; ESR1; PDCD1; PTPN22; association; severity; Rheumatology; Reumatologi; Medicine; medicin;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with systemic manifestations characterized by auto-antibodies directed against different parts of the cell nucleus including DNA, histones and ribosomes. The systemic inflammation can cause damage to multiple organs, e.g., kidneys, skin, heart, lungs and the nervous system. LÄS MER

  3. 2. Genetic analysis of type 1 diabetes susceptibilty

    Författare :Samina Asad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 1 diabetes (T1D) is a multifactorial disease where the pancreatic beta-cells are destroyed in an autoimmune attack. For the patients, this in turn leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. LÄS MER

  4. 3. Genetic analysis of candidate susceptibility genes for type 1 diabetes

    Författare :Samina Asad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 1 diabetes (T1D) is a complex disease where the pancreatic β-cells are destroyed in an autoimmune attack. For the patients, this leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. LÄS MER

  5. 4. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach

    Författare :Veronica Magnusson; Jerry Lanchbury; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). LÄS MER

  7. 5. Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases

    Författare :Ludmila Prokunina; Marta Alarcon-Riquelme; Ulf Gyllensten; Juha Kere; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; complex diseases; autoimmune diseases; genetic mapping; functional studies; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1. LÄS MER