Sökning: "Operant self-administration"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Operant self-administration.

  1. 1. Factors affecting alcohol self-administration : learning, environmental and genetic influences on behaviour

    Författare :Christopher Pickering; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ethanol; operant self-administration; addiction; reward; learning; lever press response; context; environmental cue; novelty; stress; glutamate; GABA; noradrenaline; PCR; gene expression; functional genomics; prefrontal cortex; hippocampus; amygdala;

    Sammanfattning : Alcoholism is a serious problem for society and is a very difficult disease to treat clinically. Often, the addict has periods of abstinence from alcohol followed by relapse to drinking and this cycle of use/non-use can repeat over many years. LÄS MER

  3. 2. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

    Författare :Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

    Sammanfattning : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. LÄS MER

  4. 3. From Food Preference to Craving : Behavioural Traits and Molecular Mechanisms

    Författare :Johan Alsiö; Helgi B Schiöth; Jonas Lindblom; Anna M Kindlundh-Högberg; Suzanne Dickson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; Reward; Food preferences; Dietary fats; Dietary carbohydrates; Anxiety; Dopamine; Craving; Operant self-administration; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : Preference for palatable and energy-dense foods may be a risk factor for body weight gain and has both genetic and environmental components. Once obesity develops in an individual, weight loss is difficult to achieve. LÄS MER

  5. 4. Appetite regulating neuropeptides in alcohol addiction : focus on melanin concentrating hormone and its mch1-receptor

    Författare :Camilla Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current treatment options for alcohol use disorders are limited in number and have limited efficacy. It is therefore important to find new, more effective medications. LÄS MER

  7. 5. The monoamine stabilizer (-)-OSU6162 : a potential novel treatment for alcohol use disorders

    Författare :Ida Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alcohol use disorder (AUD) represent a major health problem worldwide. Despite the severe consequences of AUD, only four medications are approved in Sweden for this disease. In addition, the prescription rates are low, partly due to varying clinical efficacy of these medications. Consequently, new, more effective pharmacotherapies are needed. LÄS MER