Sökning: "gut peptides"

Visar resultat 16 - 20 av 33 avhandlingar innehållade orden gut peptides.

  1. 16. Gut derived chronic inflammation in HIV-1 and chronic kidney disease : the role of the microbial metabolite TMAO and immunomodulatory effects of Vitamin D

    Författare :Catharina Missailidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Persistent immune activation with premature ageing and increased risk of cardiovascular disease (CVD) are features shared by HIV-1 infected individuals and patients with chronic kidney disease (CKD). Underlying dysbiosis, a failing mucosal barrier function and microbial translocation (MT) are contributing factors in both conditions. LÄS MER

  3. 17. Effect of endogenous and exogenous ghrelin on gastrointestinal function in rat and human

    Författare :Ylva Falkén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Several peptides derived from the gastrointestinal tract (GI) have been shown to have profound effects on GI motility, food intake and metabolism. Two such peptides, derived from the same prohormone, are the peptides ghrelin and obestatin, discovered in 1999 and 2005, respectively. LÄS MER

  4. 18. Studies on the effect of orexin on upper gastrointestinal function in rats and man

    Författare :Marcus Ehrström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Orexin A; orexin receptors; SB-334867-A enteric ganglia; enteroendocrine cells; migrating myoelectric complex; nitric oxide; gastric emptying; gastric acid secretion; leptin; insulin;

    Sammanfattning : Aims: To define the morphological localisation of orexin A (OXA) in the gut, and study the effect of endogenous and peripherally administered OXA on fasting small bowel motility, gastric emptying and acid secretion, hormones involved in glucose homeostasis and pharmacokinetic profile of OXA in rats and humans. Methods: The distribution of OXA, orexin receptors 1 and 2 (OX1 R, OX2R), neuronal nitric oxide synthase (nNOS) and various peptides were studied with immunocytochemistry in rat and human gut. LÄS MER

  5. 19. Comparatative studies on the IGF system in vertebrates : studies in rats, and in bony, cartilaginous, and jawless fish

    Författare :Katarina Drakenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF receptor; osteichthyes; chondrichthyes; cyclostomi; radioimmunoassay;

    Sammanfattning : Numerous studies have shown the importance of insulin-like growth factors (IGFs) for cellular growth, differentiation and metabolism in mammalian vertebrates. The mammalian IGF system, consists of IGF-1 and IGF-2, the IGF binding proteins (IGFBPs), and the type1 and type 2 IGF receptors. LÄS MER

  7. 20. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils

    Författare :Simon Lind; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophils; G protein coupled receptors; Free Fatty Acid Receptor 2; GPR43; Allosteric modulation; Transactivation; Cross-talk; Biased signalling; Functional selectivity;

    Sammanfattning : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). LÄS MER