Sökning: "migrating myoelectric complex"

Hittade 3 avhandlingar innehållade orden migrating myoelectric complex.

  1. 1. Tachykininergic and serotonergic control of the migrating motor complex : studies in rat and man

    Författare :Mikael Lördal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Small intestinal motility; MMC; human; rat; tachykinins; serotonin; 5 hydroxytryptamine; substance P; neurokinin A.;

    Sammanfattning : Small bowel motility has been studied in rats and in humans by means of electromyography and manometry. The aim was to study the effects of mammalian tachykinins and 5 hydroxytryptamine(5-HT, serotonin) on small bowel motility, with special regard to the migrating motility complex (MMC), contractile force, and transit of small bowel contents. LÄS MER

  3. 2. Ghrelin action on gastrointestinal functions and appetite in rat and man

    Författare :Fredrik Levin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ghrelin; ghrelin-receptors; gastrointestinal motility; migrating myoelectric complex; gastric acid secretion; gastric emptying; appetite; food intake; disinhibition; restraint; hunger; obesity;

    Sammanfattning : To study the effect of ghrelin on the contractility of smooth muscle strips in vitro as well as the effects on fasting small bowel motility and acid secretion in vivo in rats and gastric emptying in rats and humans. To study the effect of peripherally administered ghrelin on plasma levels of glucose, insulin, glucagon, orexin A (OXA), somatostatin and gastrin in rats and ghrelin, cholecystokinin (CCK), glucagonlike peptide-1 (GLP-1), peptide YY (PYY) and motilin in humans. LÄS MER

  4. 3. Studies on the effect of orexin on upper gastrointestinal function in rats and man

    Författare :Marcus Ehrström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Orexin A; orexin receptors; SB-334867-A enteric ganglia; enteroendocrine cells; migrating myoelectric complex; nitric oxide; gastric emptying; gastric acid secretion; leptin; insulin;

    Sammanfattning : Aims: To define the morphological localisation of orexin A (OXA) in the gut, and study the effect of endogenous and peripherally administered OXA on fasting small bowel motility, gastric emptying and acid secretion, hormones involved in glucose homeostasis and pharmacokinetic profile of OXA in rats and humans. Methods: The distribution of OXA, orexin receptors 1 and 2 (OX1 R, OX2R), neuronal nitric oxide synthase (nNOS) and various peptides were studied with immunocytochemistry in rat and human gut. LÄS MER