Sökning: "growth strategies"

Visar resultat 56 - 60 av 713 avhandlingar innehållade orden growth strategies.

  1. 56. Prevention of growth failure caused by glucocorticoids and inflammation

    Författare :Bettina Celvin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Longitudinal bone growth is a complex process that takes place in the growth plate, and normal growth is dependent on a precise balance of several endocrine and paracrine factors. Growth impairment is common in children with inflammatory diseases and is associated with elevated levels of pro-inflammatory cytokines and long-term glucocorticoid treatment. LÄS MER

  3. 57. Targeting insulin-like growth factor-1 receptor in cancer

    Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

    Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER

  4. 58. On CNS injury and olfactory ensheathing cell engraftment strategies

    Författare :I-Hui Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) is limited because of lack of nerve-growth stimulatory factors and presence of an insurmountable molecular environment for injured axons. This thesis aims to study neural regeneration following adult CNS injury, using rodent models of spinal cord injury, dorsal root avulsion, and Parkinson s disease. LÄS MER

  5. 59. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

    Författare :Elisabet I Nielsen; Lena E Friberg; Otto Cars; Mats O Karlsson; Marie Sandström; Alan Forrest; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; NONMEM; antibiotics; in vitro; time-kill curve; PK PD indices; gentamicin; aminoglycosides; newborn infants; premature infants; cystatin C; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. LÄS MER

  7. 60. Survival strategies of Mycobacterium tuberculosis inside the human macrophage

    Författare :Amanda Welin; Maria Lerm; Olle Stendahl; Peter Peters; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Mycobacterium tuberculosis (Mtb) is the bacterium responsible for tuberculosis (TB). For decades, it was believed that TB was a disease of the past, but the onset of the HIV epidemic resulting in a greatly increased number of TB cases, the emergence of antibiotic resistant Mtb strains, and the relative ineffectiveness of the BCG vaccine have put TB back on the agenda. LÄS MER