Sökning: "extracellular glutamate"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden extracellular glutamate.

  1. 1. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity

    Författare :Camilla Wallin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glutathione; excitotoxicity; hypoxia-ischemia; brain; rat; anoxia-aglycemia; g-glutamyl transpeptidase; glutamate; NMDA; oxidative stress; mitochondria; amino acids;

    Sammanfattning : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. LÄS MER

  3. 2. GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN

    Författare :Malin Stridh; Göteborgs universitet; []
    Nyckelord :astrocyte; antioxidant; connexin; hemichannel; glutathione; efflux; glutamate;

    Sammanfattning : The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e. LÄS MER

  4. 3. Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions

    Författare :Mikael Persson; Göteborgs universitet; []
    Nyckelord :anaphylatoxin; central nervous system; herpes simplex virus; glutamate transport; glutathione; GLT-1; lipopolysaccharide; microglia; neuroinflammation; oxidative stress; protection; tumour necrosis factor-alpha;

    Sammanfattning : Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly and specifically react to any disturbances such as brain trauma, ischemia, neurodegenerative diseases, or infections. LÄS MER

  5. 4. Assessment of experimental neurotrauma

    Författare :Ying-Lai Huang; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Impulse noise; diffuse brain injury; focal brain injury; closed head injury; NSE; S-100; GFAP; apoptosis; astrocytosis; glutamate; c-JUN; rotational acceleration; CSF;

    Sammanfattning : Model systems of closed head injury are designed to replicate aspects of traumatic brain injury, ischemia and epilepsy in man. The aim of this thesis was to (1) develop sensitive systems enabling analyses of the biochemical reactions, as reflected by leakage of marker compounds to the cerebrospinal fluid (CSF); and (2) develop and assess a new model for closed head injury and associated dynamic changes in the brain cell. LÄS MER

  7. 5. Astrocyte-mediated short-term synaptic depression

    Författare :My Andersson; Göteborgs universitet; []
    Nyckelord :glutamate; glia; plasticity; synapse; hippocampus;

    Sammanfattning : Short-term synaptic plasticity, the activity-dependent regulation of synaptic efficacy that occurs in the timeframe of milliseconds to seconds, is a fundamental property of the synapse, mostly attributed to changes in release probability. These changes are commonly ascribed to intrinsic mechanisms in the presynaptic terminal and to different transmitters acting on the presynaptic terminal. LÄS MER