Sökning: "extra cellular matrix"

Visar resultat 21 - 25 av 34 avhandlingar innehållade orden extra cellular matrix.

  1. 21. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Författare :Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. LÄS MER

  3. 22. FoxF genes in development and disease

    Författare :Seyed Ali Moussavi Nik; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; FOXF1; Sfrp1; LGR5 stem cells; Tgfb; Wnt signaling; ECM; Intact intestinal epithelium; Foxf2; ACDMPV;

    Sammanfattning : Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings about the mechanism of action of FoxF genes in development and disease. LÄS MER

  4. 23. Interaction of Heparan Sulfate with Pro- and Anti-Angiogenic Proteins

    Författare :Maarten Vanwildemeersch; Dorothe Spillmann; Ulf Lindahl; Anders Aspberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; angiogenesis; fibroblast growth factors; endostatin; histidine-rich glycoprotein; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Heparan sulfate (HS) is an unbranched and negatively charged polysaccharide of the glycosaminoglycan family, based on the repeated (GlcNAcα1-4GlcAβ1-4) disaccharide structure. The HS backbone is modified by epimerization and sulfation in various positions. LÄS MER

  5. 24. Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer

    Författare :Sofie Björner; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. LÄS MER

  7. 25. The cyanobacterial pigments scytonemin and nostodione A - Synthesis, photophysicochemical behavior and biological studies

    Författare :Andreas Ekebergh; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; UV-screeners; design of experiments; cascade reactions; palladium catalysis; nostodione A; ligand effect; gold catalysis; kinase inhibitor; Scytonemin; photo-stability;

    Sammanfattning : The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UV-protective ability allows the bacteria to thrive in inhospitable locations exposed to intense solar radiation. Scytonemin has a dimeric structure consisting of two 1-1' linked 3-(4-hydroxybenzylidene)cyclopenta[b]indole-2-one moieties. LÄS MER