Sökning: "dual targeting"
Visar resultat 11 - 15 av 61 avhandlingar innehållade orden dual targeting.
11. Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence
Sammanfattning : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. LÄS MER
12. Therapeutic response in human cancers : the dual role of STAT signalling
Sammanfattning : STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects by regulating gene transcription. LÄS MER
13. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer
Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER
14. Understanding the response to EGFR targeting therapy in non-small-cell lung cancer using -omics approach
Sammanfattning : NSCLC is the leading cause of cancer-related death worldwide. EGFR targeted therapy is used to inhibit the progress of NSCLC, but patients inevitably develop resistance to EGFRTKIs. LÄS MER
15. When the bear lost its tail : targeting the GRK/β-arrestins downstream IGF1R in non-epithelial malignancies
Sammanfattning : Plasma membrane receptors are highly specialized cell surface structures that receive extracellular information and process them into biological responses. Among them, this thesis focuses on two major receptor families: the G protein-coupled receptors (GPCR) and the receptor tyrosine kinases (RTKs). LÄS MER
