Sökning: "dissection"

Visar resultat 16 - 20 av 180 avhandlingar innehållade ordet dissection.

  1. 16. Genetic dissection of experimental arthritis in the DA rat

    Författare :Liselotte Bäckdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :RA; Experimental arthritis; QTL; congene; Aplec; > human association;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting peripheral joints. Persistent inflammation causes cartilage deterioration with severe joint deformations as a consequence. The etiology is largely unknown but complex interactions between genetic and environmental factors contribute to the disease. LÄS MER

  3. 17. Genetic dissection of experimental autoimmune neuroinflammatory diseases in rats

    Författare :Ingrid Dahlman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS) causing neurological deficits. The disease has a complex etiology comprising multiple unidentified susceptibility genes and environmental influences. LÄS MER

  4. 18. Genomic strategies towards the dissection of human complex disease

    Författare :Tesfai Emahazion; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mapping; complex disease; polymorphism; SNP; association analysis; Alzheimer s disease; oxidative phosphorylation; apoptosis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Complex diseases are caused by the activities of many genes acting in concert with environmental factors. A major challenge facing human genetic research is to unravel the genetic factors behind complex disorders. LÄS MER

  5. 19. Genetic dissection of multifactorial disease models in the rat

    Författare :Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

    Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER

  7. 20. Molecular dissection of B-lymphocyte signalling using expression profiling

    Författare :Jessica M Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Btk; B-lymphocyte; gene expression profiling; signal transduction;

    Sammanfattning : Gene expression profiling and bioinformatics have emerged into playing a large and diverse role in many aspects of both the clinical and molecular research. These two approaches have in this thesis work been used in combination in order to shed light to the role of Bruton's tyrosine kinase (Btk) in B-lymphocyte development and signal transduction. LÄS MER