Sökning: "Aplec"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Aplec.

  1. 1. Genetic dissection of experimental arthritis in the DA rat

    Författare :Liselotte Bäckdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :RA; Experimental arthritis; QTL; congene; Aplec; > human association;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting peripheral joints. Persistent inflammation causes cartilage deterioration with severe joint deformations as a consequence. The etiology is largely unknown but complex interactions between genetic and environmental factors contribute to the disease. LÄS MER

  3. 2. Identification of genes that regulate arthritis and IgE production in rat and human

    Författare :Ulrica Ribbhammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :RA; experimental animal model; QTL; congenic strain; APLEC; asthma; total IgE;

    Sammanfattning : Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), which was originally identified in a genomewide linkage analysis in oil-induced arthritis (OIA), a model that shows similarities to rheumatoid arthritis (RA) in human. LÄS MER

  4. 3. Genetic and immunological studies of experimental arthritis, with emphasis on a novel C-type lectin receptor gene complex

    Författare :Jian Ping Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune syndrome primarily affecting peripheral joints. The etiology of RA is largely unknown but complex interactions between genetic and environmental factors contribute to the disease. Arthritis models more or less resembling RA are used to search for clues. LÄS MER

  5. 4. Impact of genetic variability on early immune reactions following nerve injury

    Författare :Rickard P F Lindblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Injury to the central nervous system (CNS) is frequently associated with significant morbidity, in worst case mortality. This in turn leads to considerable disease burden for the individual and also for society. LÄS MER

  7. 5. Genetic regulation of autoimmunity in experimental neuroinflammation

    Författare :Sevasti Flytzani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system causing axonal demyelination and leads to significant disabilities. MS affects mainly young adults and incidence of disease in Sweden is around 600 new cases/year. LÄS MER