Sökning: "Pedro Alzari"

Hittade 2 avhandlingar innehållade orden Pedro Alzari.

  1. 1. Structural Studies of a Xyloglucan Endotransglycosylase from Populus tremula x tremuloides and Three Conserved Hypothetical Proteins from Mycobacterium tuberculosis

    Författare :Patrik Johansson; Alwyn Jones; Sherry Mowbray; Pedro Alzari; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; xyloglucan endotransglycosylase; Mycobacterium tuberculosis; epoxide hydrolase; fatty acid metabolism; fatty acid oxidation; crystallography; Cell- och molekylärbiologi;

    Sammanfattning : This thesis describes the structural studies of four different proteins from two organisms. Xyloglucan endotransglycosylases, XETs, are involved in plant cell wall expansion and remodeling by splitting and reconnecting xyloglucan-cellulose crosslinks. The first crystal structure of a XET enzyme has been determined to 1.8 Å. LÄS MER

  3. 2. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

    Författare :Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

    Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER