Sökning: "FAS II"
Visar resultat 1 - 5 av 83 avhandlingar innehållade orden FAS II.
1. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides : Applications to Angiotensin II
Sammanfattning : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. LÄS MER
2. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden
Sammanfattning : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. LÄS MER
3. Endogenous proteins as markers of glomerular function and dysfunction
Sammanfattning : Plasma and urine concentrations of endogenous proteins are frequently used in the diagnosis of kidney diseases and in studies of glomerular filter function. The main issues addressed in these studies were: storage of urine samples for subsequent protein analysis, use of protein concentrations in urine and in plasma in health and as markers of glomerular diseases, and the application of renal plasma-to-urine clearance of endogenous proteins in estimating the size-selectivity properties of the glomerular capillary wall. LÄS MER
4. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins
Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER
5. Tissue kallikrein: pathophysiological role in acute pancreatitis
Sammanfattning : Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. LÄS MER