Sökning: "c-Kit Kit Ligand"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden c-Kit Kit Ligand.

  1. 1. Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells

    Författare :Charlotte Edling; Bengt Hallberg; Pontus Aspenström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RTK; c-Kit; MAPK; PI3K; PKC; hematopoietic cells; proliferation; differentiation; apoptosis; Pathology; Patologi;

    Sammanfattning : The receptor tyrosine kinase (RTK) c-Kit is expressed in hematopoietic stem and progenitor cells, mast cells and in several non-hematopoietic tissues. In the hematopoietic system c-Kit and its ligand Steel Factor (SF, aka Stem Cell Factor) are critical for proliferation, survival and differentiation. LÄS MER

  3. 2. The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells

    Författare :Lina Thorén; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thrombopoietin; hematopoiesis; Thpo; c-kit; stem cells;

    Sammanfattning : The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per day, illustrating the high turnover within the hematopoietic system and the need for replenishments by HSCs. LÄS MER

  4. 3. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells

    Författare :Richard Karlsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; hypoxia.; forkhead; Akt PKB; Bcl-2; apoptosis; Flt3; FL; c-kit; KL; cytokines; Hematopoiesis; progenitor;

    Sammanfattning : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. LÄS MER

  5. 4. Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways

    Författare :Maria Kraft; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokines; apoptosis; cell cycle; c-Kit; Flt3; Flt3-ITD; Akt; Bcl-2; FoxO3; mouse; hematopoiesis; progenitor;

    Sammanfattning : Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. LÄS MER

  7. 5. C-Kit as an Oncogenic Tyrosine Kinase - Regulation and Dysregulation of Signaling Pathways

    Författare :Malin Pedersen; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. LÄS MER