Sökning: "FoxO3"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet FoxO3.

  1. 1. Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways

    Författare :Maria Kraft; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokines; apoptosis; cell cycle; c-Kit; Flt3; Flt3-ITD; Akt; Bcl-2; FoxO3; mouse; hematopoiesis; progenitor;

    Sammanfattning : Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. LÄS MER

  3. 2. Gene regulation in normal and malignant B-lineage cells

    Författare :Lucía Peña Pérez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : B-cells are the central players of humoral immunity. It is known that their development is orchestrated by a small group of transcription factors including the E-proteins and the FOXO proteins, yet this process is far from completely understood. LÄS MER

  4. 3. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells

    Författare :Richard Karlsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; hypoxia.; forkhead; Akt PKB; Bcl-2; apoptosis; Flt3; FL; c-kit; KL; cytokines; Hematopoiesis; progenitor;

    Sammanfattning : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. LÄS MER

  5. 4. Understanding the heterogeneity of the hematopoietic stem cells

    Författare :Ece Somuncular; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The hematopoietic system is replenished and maintained throughout life by rare hematopoietic stem cells (HSCs) that reside in the bone marrow (BM) of adult mammals. Over the last 20 years, the advancement in the field lead to the acknowledgement of the heterogeneity within the HSC compartment unraveling the presence of HSC subsets with certain mature blood lineage preferences so called lineage-biased (Li-bi) HSCs. LÄS MER

  7. 5. Skeletal muscle plasticity and energy metabolism

    Författare :Leonidas S Lundell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, which in turn can both damage cells and convey signals. LÄS MER