Sökning: "FL"

Visar resultat 1 - 5 av 149 avhandlingar innehållade ordet FL.

  1. 1. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells

    Författare :Richard Karlsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; hypoxia.; forkhead; Akt PKB; Bcl-2; apoptosis; Flt3; FL; c-kit; KL; cytokines; Hematopoiesis; progenitor;

    Sammanfattning : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. LÄS MER

  3. 2. Maintenance and Commitment of Hematopoietic Progenitors: Role of flt3, c-kit and c-mpl

    Författare :Ole Johan Borge; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KL; hematopoiesis; FL; cytokines; B-cells; commitment; flt3; differentiation; Haematology; IL-7; c-kit; progenitors; Hematologi; stem cells; thrombopoietin; viability; extracellular fluids; extracellulära vätskor;

    Sammanfattning : The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). LÄS MER

  4. 3. Fault location in resonant earthed medium voltage distribution systems

    Författare :Md Zakaria Habib; Nathaniel Taylor; Mohamed F. Abdelfattah; Matti Lehtonen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electrical distribution; Distribution network; Reliability; SAIDI; Fault location; FL; Fault passage indicator; FPI; Compensated neutral; Resonant earthing; Resonant grounding; Petersen coil; Arc suppression coil.; Distributionsnät; Tillförlitlighet; Fellokalisering; FL; Felpassageindikation; FPI; Kompenserat nät; Spoljordat nät; Petersenspole.; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : A major challenge in electric distribution systems is to increase the reliability of the electricity supply in an economical way. At the final medium-voltage level in the system, such as 10 kV or 20 kV, a single feeder may supply tens of medium/low-voltage transformers and hundreds of customers, with many branches of lines and cables where faults can occur. LÄS MER

  5. 4. Regulation of human mast cell development

    Författare :Malin Hjertson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mast cells; hematopoiesis; chemotaxis; SCF; FL; GM-CSF; IL-3; RA; SDF-1; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mast cells are multifunctional effector cells of the immune system and are best known for theirparticipation in allergic reactions. The aim of this thesis was to investigate how the stem cell factor(SCF)-dependent development of mast cells from cord blood can be regulated by different factors, and tostudy how immature mast cells circulating in the blood can be recruited into the tissue. LÄS MER

  7. 5. Fabrication advances of microvasculature models on-chip

    Författare :Federico Cantoni; Maria Tenje; Niels Larsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 2-photon polymerization 3D printing; multi-hydrogel structure; vascula-ture model; microphysiological systems; organ-on-chip;

    Sammanfattning : Despite the technological advances of the last decades, drug development remains a lengthy and costly process with uncertainties still associated with the poor predictive power of the in vitro and animal models. To address this limitation, microphysiological systems have been introduced in an attempt to increase the biological relevance of in vitro devices. LÄS MER