Sökning: "brain slice cultures"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden brain slice cultures.

  1. 1. Mechanisms of Ischemic Brain Injury- studies in murine hippocampal slice cultures

    Författare :Anna Rytter; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neuropsychology; Neurology; adenosine; caspases; hypothermia; in vitro; hippocampus; ischemia; neurofysiologi;

    Sammanfattning : Cerebral ischemia is a major cause of mortality and morbidity in the western world. Even though much effort has been put into research and development of effective drugs against ischemic damage there is to date no effective pharmacological brain protective treatment. LÄS MER

  3. 2. N-acetylaspartate in brain - studies on efflux and function

    Författare :Mattias Tranberg; Göteborgs universitet; []
    Nyckelord :N-acetylaspartate; Hippocampal slice cultures; HPLC; NMDA; Excitotoxicity; Volume regulation; Canavan disease;

    Sammanfattning : N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. LÄS MER

  4. 3. Exploring Direct Conversion of Human Glia into Therapeutic Neurons

    Författare :Jessica Giacomoni; Utvecklings- och regenerativ neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; glial progenitor cells; neuronal reprogramming; induced neurons; spheroids; brain slice cultures; neurodegenerative disorders;

    Sammanfattning : Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. LÄS MER

  5. 4. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

    Författare :Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. LÄS MER

  7. 5. Auditory organotypic cultures and progenitor cell implantation

    Författare :Andreas Kaiser; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : According to the WHO, about 5 % of the world’s population suffers from disabling hearing loss. In people above the age of 65 the number is more than 30 %. Common effects of this condition are poor speech discrimination and impaired communication abilities. Patient surveys show that hearing loss often leads to a diminished quality of life. LÄS MER