Sökning: "azathioprine"

Visar resultat 6 - 10 av 23 avhandlingar innehållade ordet azathioprine.

  1. 6. Development of new methodology for therapeutic drug monitoring of thiopurine treatment

    Författare :Svante Vikingsson; Curt Peterson; Björn Carlsson; Martin Josefsson; Sven Almer; Johan Ahlner; Lynne Lennard; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thiopurines; mercaptopurine; thioguanine; azathioprine; crohn s disease; ulcertive colitis; HPLC; TGN;

    Sammanfattning : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). LÄS MER

  3. 7. Epidemiological and therapeutic aspects of Inflammatory Bowel Disease

    Författare :Carl Eriksson; Jonas Halfvarson; Scott Montgomery; Flemming Bendtsen; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; ulcerative colitis; Crohn’s disease; cohort study; population-based; colectomy; disease course; anaemia; azathioprine; 6-mercaptopurine; vedolizumab;

    Sammanfattning : Introduction: The two main forms of inflammatory bowel disease (IBD) are Crohn’s disease and ulcerative colitis. These are chronic inflammatory disorders, mainly affecting the gastrointestinal tract. LÄS MER

  4. 8. Surgery and immuno modulation in Crohn’s disease

    Författare :Pär Myrelid; Johan D. Söderholm; Peter Andersson; Rune Sjödahl; Bruce George; Linköpings universitet; []
    Nyckelord :Crohn’s disease; surgery; immuno modulation; complications; stoma; anastomosis; DSS; bursting pressure; MEDICINE; MEDICIN;

    Sammanfattning : Crohn’s disease is a chronic inflammatory bowel disease with unknown origin. This study investigates the combined use of surgery and immuno modulation in Crohn’s disease. The outcome of medication and surgery in 371 operations on 237 patients between 1989 and 2006 were evaluated. LÄS MER

  5. 9. Pharmacoepidemiologic studies of drug safety in pediatric chronic inflammatory disease

    Författare :Viktor Wintzell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Safety evidence for use of pharmaceutical drugs in children, including treatments for serious conditions such as chronic inflammatory diseases, is generally scarce. Off-label use is common and clinicians need to rely on evidence from adults when prescribing to children. LÄS MER

  7. 10. Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase

    Författare :Malin Lindqvist Appell; Michel Eichelbaum; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. LÄS MER