Sökning: "immuno modulation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden immuno modulation.

  1. 1. Surgery and immuno modulation in Crohn’s disease

    Författare :Pär Myrelid; Johan D. Söderholm; Peter Andersson; Rune Sjödahl; Bruce George; Linköpings universitet; []
    Nyckelord :Crohn’s disease; surgery; immuno modulation; complications; stoma; anastomosis; DSS; bursting pressure; MEDICINE; MEDICIN;

    Sammanfattning : Crohn’s disease is a chronic inflammatory bowel disease with unknown origin. This study investigates the combined use of surgery and immuno modulation in Crohn’s disease. The outcome of medication and surgery in 371 operations on 237 patients between 1989 and 2006 were evaluated. LÄS MER

  3. 2. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

    Författare :Anna Eriksson; Göteborgs universitet; []
    Nyckelord :adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

    Sammanfattning : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. LÄS MER

  4. 3. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

    Författare :Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. LÄS MER

  5. 4. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  7. 5. Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression

    Författare :Ann-Christin Stenqvist; Lucia Mincheva-Nilsson; Maria Jenmalm; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exosomes; microvesicles; pregnancy; placenta; syncytiotrophoblast; immune privilege; apoptosis; cytotoxicity; T regulatory cells; NKG2D; MICA B; FasL; TRAIL; immunologi; Immunology;

    Sammanfattning : The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. LÄS MER