Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Författare :Michael Jewett; Translationell Neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

  3. 2. Genetic dissection of models for neuroinflammation and neurodegeneration

    Författare :Karin Harnesk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Many central nervous system (CNS) diseases are characterized by inflammation and nerve cell loss, but the exact relationship between these phenomena is not known. The complex etiology of CNS disorders includes a genetic component. LÄS MER

  4. 3. Genetic regulation of nerve injury-induced neurodegeneration and inflammation

    Författare :Maria Swanberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodegeneration and inflammation in the central nervous system (CNS) are hallmarks of several neurological disorders, including multiple sclerosis (MS), Alzheimer’s disease and Parkinson’s disease. The susceptibility of an individual to these conditions is complex, i.e. influenced by both genetic and environmental factors. LÄS MER

  5. 4. Genetics and inflammation in nerve injury-induced neurodegeneration

    Författare :Olle Lidman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Motoneuron; Neurodegeneration; Immunity; Microglia; MHC; QTL Mapping.;

    Sammanfattning : Neurodegeneration and inflammation are characteristic of many diseases of the central nervous system (CNS) and understanding the molecular networks that regulate these processes is of central importance for the development of effective therapies. Although the CNS has traditionally been regarded as an immuno privileged organ, immune reactions, including components of both local innate and systemic immunity, do occur in this tissue. LÄS MER