Sökning: "Treg"

Visar resultat 31 - 35 av 88 avhandlingar innehållade ordet Treg.

  1. 31. Immune tolerance by interferon-alpha in experimental arthritis

    Författare :Jaya Prakash Chalise; Mattias Magnusson; Thomas Skogh; Richard O Williams; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Type I Interferons (mainly IFN-α & IFN-β) belong to a family of cytokines that possess strong antiviral and immunomodulatory properties. Pro- and/or anti-inflammatory effects of type I IFN have been observed in infectious diseases and several autoimmune diseases including SLE, MS, RA and experimental models thereof, but what defines either outcome is largely obscure. LÄS MER

  3. 32. Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression

    Författare :Ann-Christin Stenqvist; Lucia Mincheva-Nilsson; Maria Jenmalm; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exosomes; microvesicles; pregnancy; placenta; syncytiotrophoblast; immune privilege; apoptosis; cytotoxicity; T regulatory cells; NKG2D; MICA B; FasL; TRAIL; immunologi; Immunology;

    Sammanfattning : The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. LÄS MER

  4. 33. Adaptive immunity in urothelial cancer : molecular and clinical aspects

    Författare :David Krantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the immune system against each other; suppressive cells such as regulatory T cells (Tregs) are hijacked to obstruct effector lymphocytes in their attempt to eradicate the tumor. LÄS MER

  5. 34. Platelet-regulated CD4+ T effector cell responses in atherosclerosis

    Författare :Shuai Tan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis (AS) is a thrombotic and inflammatory disease of the medium- and largesized arteries. Platelets participate in all stages of its formation, forming thrombus at the ruptured plaque; meanwhile, CD4+ T cells are a key driving force of inflammation, plaque formation and instability. LÄS MER

  7. 35. Immune regulation at the foetal-maternal interface; implications for healthy and complicated pregnancies

    Författare :Robert Lindau; Jan Ernerudh; Maria Jenmalm; Kristina Nilsson-Ekdahl; Petra Arck; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : For a successful pregnancy, the maternal immune system must acquire tolerance towards the paternal antigens present in the semi-allogeneic foetus. This tolerance is mainly established locally at the foetal-maternal interface, where foetally-derived trophoblasts invade the maternal endometrium (called decidua during pregnancy) and come in close proximity to maternal immune cells. LÄS MER