Sökning: "immune privilege"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden immune privilege.
1. Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression
Sammanfattning : The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. LÄS MER
2. Immune regulation within the central nervous system and its role in demyelinating diseases
Sammanfattning : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are diseases of the central nervous system (CNS) characterized by perivascular mononuclear inflammation and oligodendrocyte loss with demyelination. However, it is still not clear whether the pathology in MS and EAE is due to neuroantigen-specific CD4+ T cell-mediated autoimmune responses and/or bystander myelin damage resulting from an inflammatory response. LÄS MER
3. The anterior chamber of the eye as an islet transplantation site in type-2 diabetes
Sammanfattning : Diabetes mellitus is a chronic disease, one of the leading causes of death and a consistent financial burden globally. It occurs when insulin is insufficient for glucose homeostasis. Pancreatic islet transplantation drew attention as an attractive therapeutic option for treating Type-1 diabetes. LÄS MER
4. Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells
Sammanfattning : Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been or are being tested in clinical trials. LÄS MER
5. Spinal motoneurons and molecules related to neurotrophic function after axon injury
Sammanfattning : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. LÄS MER