Sökning: "Treg"
Visar resultat 11 - 15 av 88 avhandlingar innehållade ordet Treg.
11. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells
Sammanfattning : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). LÄS MER
12. Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease
Sammanfattning : Type 1 diabetes (T1D) is etiologically considered as an autoimmune disease, where insulin-producing β-cells are damaged by autoimmune attacks. Regulatory T (Treg) cells are immune homeostasis cells. In the present thesis I aimed to investigate the role of Treg cells and other immune cells in the early development of T1D. LÄS MER
13. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood
Sammanfattning : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. LÄS MER
14. Reign in Blood : Immune Regulation in Type 1 Diabetes
Sammanfattning : Type 1 Diabetes (T1D) is an autoimmune disease resulting in insulin deficiency as a result ofautoimmune destruction of pancreatic β-cells. Preserving β-cell function in patients with T1D would be of great benefit since patients with sustained endogenous insulin secretion are known to suffer less from secondary complications due to hyperglycemia. LÄS MER
15. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
Sammanfattning : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. LÄS MER