Sökning: "Thyroid hormone receptor alpha"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Thyroid hormone receptor alpha.

1. 1. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

   Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

   Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER

3. 2. Expression and function of thyroid hormone receptor alpha 1 in the brain

   Författare :Karin Wallis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Thyroid hormone is fundamentally important for development and maintenance of adult brain functions and maternal hypothyroxinemia during pregnancy can lead to a severe mental retardation known as endemic cretinism. The first realization that endemic cretinism is caused by iodine deficiency and its association with thyroid hormone was made a century ago; this eventually resulted in dietary supplementation programme, e. LÄS MER

4. 3. Thyroid hormone receptors in liver metabolism

   Författare :Hjalmar Gullberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Thyroid hormone has a profound impact on mammalian metabolism; hypothyroidism causes decreased metabolic rate and increased serum cholesterol levels. One major target organ for the hormone is the liver, the most important metabolic organ in mammals, that balances anabolism of carbohydrates and lipids against catabolism. LÄS MER

5. 4. Selenium and Breast Cancer. Is It Protective? Epidemiologic Evidence Regarding Risk and Prognosis

   Författare :Malte Sandsveden; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast neoplasms; Selenium; Epidemiology; cancer biomarkers; Single nucleotide polymophisms; Thyroid hormone receptor alpha; Dietary selenium intake; Serum selenium; Genetic Risk;

   Sammanfattning : .... LÄS MER

7. 5. Thyroid hormones and their receptors in transcriptional regulation

   Författare :Monika Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Thyroid hormone receptor; regulatory response element; palindrome; directrepeat; everted repeat; DNA hinding domain; P75gag-v-erbA; differentiation; nuclearlocalization; repression.;

   Sammanfattning : The thyroid hormone receptors (TRs) are encoded by two genes, alpha and ß, and belong to a family of hormone activated nuclear receptors. This family includes the receptors for retinoids and vitamin D3 as well as the receptors for steroid hormones. LÄS MER