Sökning: "Small heat shock protein"

Visar resultat 16 - 20 av 26 avhandlingar innehållade orden Small heat shock protein.

  1. 16. Topographical study of intranuclear distribution and compartementalization of viral and cellular proteins

    Författare :Wei-Qin Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclei of eukaryotic cells contain a number of specialized domains involved in DNA replication, transcription, pre-mRNA splicing and ribosome assembly. In addition to these structures, nuclear bodies of unknown function have been described. LÄS MER

  3. 17. Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells

    Författare :Sara Ståhl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : To combat lung cancer (LC) which is the number one cancer associated killer, a combination of surgery, chemotherapy, radiotherapy and targeted agents are currently used. The main subtype of LC, Non small cell lung cancer (NSCLC) unfortunately responds poorly to conventional radiotherapy (RT) for reasons yet only partly understood. LÄS MER

  4. 18. Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment

    Författare :Lothar Dieterich; Anna Dimberg; Lena Claesson-Welsh; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stroma; glioma; alphaB-crystallin; HSPB5; cryab; myeloid cells; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as inflammatory cells, endothelial cells and fibroblasts, which can either inhibit or promote tumor growth. LÄS MER

  5. 19. Endothelial activation and inflammation in the tumor microenvironment

    Författare :Hua Huang; Anna Dimberg; William C. Aird; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor angiogenesis; endothelial activation; leukocyte recruitment; VEGF-A; αB-crystallin; ELTD1;

    Sammanfattning : Tumors are composed not only of malignant cells, but also of various types of normal cells, including vascular cells and infiltrating immune cells, which drive tumor development and progression. The tumor vasculature is abnormal and dysfunctional due to sustained tumor angiogenesis driven by high levels of pro-angiogenic factors. LÄS MER

  7. 20. The release of histone proteins from cells via extracellular vesicles

    Författare :Uma Muthukrishnan; Jonathan Gilthorpe; Miles Trupp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone; extracellular vesicles; exosomes; extracellular histones extracellular DNA; cellular stress; proteomics; ESCRT complex; Lrrn1; mid-hindbrain organizer; ovarian cancer; ascites;

    Sammanfattning : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. LÄS MER