Sökning: "SIRT2"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet SIRT2.

1. 1. Design, Synthesis, and Evaluation of Functionalized Chroman-4-one and Chromone Derivatives. Somatostatin receptor agonists and Sirt2 inhibitors

   Författare :Maria Fridén-Saxin; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chroman-4-ones; Chromones; Inhibitors; Molecular Modeling; Peptidomimetic; Samarium; Sirtuin; Sirt2; Somatostatin; Structure-Activity Relationships; Tubulin; β-Turn;

   Sammanfattning : Peptides are involved in many physiological processes such as regulation of blood-pressure, food intake, pain transmission and blood-glucose levels. They consist of amino acids that are connected through amide bonds which make peptides hydrophilic and conformationally flexible. LÄS MER

3. 2. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

   Författare :Tina Seifert; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

   Sammanfattning : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. LÄS MER

4. 3. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

   Författare :Limin Ma; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. LÄS MER

5. 4. Sleep-disordered breathing in women : Associations with cardiovascular disease and the significance of sleep apnea during REM sleep

   Författare :Mirjam Ljunggren; Eva Lindberg; Christer Janson; Eva Svanborg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstructive sleep apnea; REM sleep; cardiovascular disease; heart failure; Lungmedicin; Lung Medicine;

   Sammanfattning : Background: Sleep-disordered breathing (SDB) is associated with an increased risk of cardiovascular disease, but it is unclear which elements of SDB that are most harmful to the cardiovascular system and whether the associations observed in men also apply to women.Aim: To investigate associations between different aspects of SDB and cardiovascular disease in womenMethods and results: All four papers were based on participants in “Sleep and Health in Women” (SHE), a population-based cohort study of women. LÄS MER

7. 5. Small molecules that affect the p53 pathway and their potential use in the treatment of cancer

   Författare :Marijke Cornelia Christine Sachweh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor suppressor p53 was identified 35 years ago and has since then been studied extensively, but despite all efforts, no drug or therapy directly involving it has been clinically approved - yet! A lot of potential new drugs are on their way that can reactivate p53 function by various mechanisms. Even a whole new approach called cyclotherapy has been established, during which p53 is activated in normal cells to protect patients from the adverse effects of chemotherapy while tumor cells are still being killed efficiently. LÄS MER