Sökning: "Ribosome biogenesis"

Visar resultat 11 - 15 av 43 avhandlingar innehållade orden Ribosome biogenesis.

1. 11. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

   Författare :Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

   Sammanfattning : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. LÄS MER

3. 12. Cotranslational protein biogenesis in Escherichia coli monitored by force profile analysis

   Författare :Felix Nicolaus; Gunnar von Heijne; Ross Dalbey; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; cotranslational protein biogenesis; membrane protein; soluble protein; transmembrane helices; force profile analysis; arrest peptide; biokemi; Biochemistry;

   Sammanfattning : Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. LÄS MER

4. 13. Not just protein factories : role of ribosome biogenesis as an architect of epithelial-mesenchymal transition and breast cancer progression

   Författare :Varsha Prakash; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : RNA polymerase I (Pol I)-mediated transcription of ribosomal DNA (rDNA) is considered to be the rate-limiting step in ribosome biogenesis and is a well-known hallmark of cell growth and proliferation. The process of synthesizing new ribosomes is executed by the coordination of multiple complex processes in the nucleolus. LÄS MER

5. 14. RNA Polymerase I regulation by chromatin remodelling

   Författare :Yuan Guo; Ann-Kristin Östlund Farrants; Marikki Laiho; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Pol I; ribosome genes; chromatin remodelling; WSTF; CHD4; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Cell proliferation and growth is correlated with effective protein synthesis and ribosome biogenesis. The transcription of the 47S pre-ribosomal RNA by RNA Polymerase I (RNA Pol I) machinery is the rate-limiting step of ribosome biogenesis and can accounts for more than 50% of total cellular transcription. LÄS MER

7. 15. Biogenesis of messenger and ribosomal RNPs in the eukaryotic cell

   Författare :Petra Björk; Juan Valcárcel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Physical Biology; fysikalisk biologi;

   Sammanfattning : In eukaryotic cells, gene expression involves multi-step processes in the nucleus and the cytoplasm. The different processes engage specific RNA-protein complexes, RNPs. Upon activation of most, if not all genes, a precursor RNA molecule is synthesized that has to be extensively processed and modified. LÄS MER