Sökning: "ROH"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ROH.

  1. 1. Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients

    Författare :Hyung-Keun Roh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; phenotype; genotype; CYP2D6; CYP2C 19; Korean; haloperidol; risperidone; omeprazole; gastric pH; gastrin; schizophrenia; patient.;

    Sammanfattning : This thesis aimed to investigate the relationship between pheno- and genotype of two drugmetabolizing enzymes CYP2D6 and CYYP2C19 in Koreans. Population studies were conducted in healthy volunteers to obtain basic information on these two enzymes. LÄS MER

  3. 2. Divergence, selection, demographic history and conservation genomics of sibling bird species in boreal forest in Northern Eurasia and the Qinghai-Tibetan Plateau

    Författare :Kai Song; Jacob Höglund; Yue Hua Sun; Peter Halvarsson; Juha Merilä; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sichuan Jay; Siberian Jay; Chinese Grouse; Hazel Grouse; genomics; demographic history; ROH; genetic load;

    Sammanfattning : I used two pairs of sibling boreal forest bird species to study divergence, selection, demographics, and conservation in northern Eurasia and the Qinghai-Tibetan Plateau at the microsatellite level (chapter 1) and whole genome level (chapters 2, 3, 4 and 5). In chapter 1, which is the first study to describe genetic diversity of the Sichuan Jay, I used microsatellite markers to estimate genetic differentiation in Sichuan Jay and Siberian Jay populations. LÄS MER

  4. 3. Studies on cellular vitamin A metabolism and effects of UV irridation in human keratinocytes and melanocytes

    Författare :Eva Andersson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Reinoids (vitamin A and its derivatives) are modulators of proliferation and differentiation in a variety of cell types, including epidermal cells. Both retinol (ROH) and its metabolite 3,4-didehydroretinol (ddROH) can be converted to the acid form retinoic acid (RA) and 3,4-didehydroretinoic acid (ddRA), ligands for the nuclear receptors inducing gene transcriptions. LÄS MER

  5. 4. Vitamin A and ß-carotene metabolism and effects of UV irradiation in human keratinocytes and melanocytes

    Författare :Eva Andersson; Helen Håkansson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Retinoids (vitamin A and its derivatives) are modulators of proliferation and differentiation. Both retinol (ROH) and its metabolite 3,4-didehydroretinol (ddROH) can be converted to retinoic acid (RA) and 3,4-didehydroretinoic acid (ddRA), ligands for the nuclear receptors, which induce gene transcriptions. LÄS MER

  7. 5. Bolivian creole cattle: population structure, genetic diversity and management practices

    Författare :Gabriela Bottani; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Characterization studies of local livestock breeds are important to identify their potential and value for the Global Animal Genetic Resources. Important traits have been attributed to local breeds including adaptability and resilience to harsh environments and other traits with potential use in breeding schemes oriented towards the challenges of climate change. LÄS MER