Sökning: "RNase H"
Visar resultat 21 - 22 av 22 avhandlingar innehållade orden RNase H.
21. Peptide nucleic acid conjugates as artificial ribonucleases : Cu2+ and Zn2+-dependent PNAzymes
Sammanfattning : Synthetic modified oligonucleotides are gaining momentum as powerful therapeutic tools used in the treatment of life-threatening diseases. Degradation of disease-related RNA sequences is one of the goals achieved with oligonucleotide therapeutics, albeit the currently available technologies rely on the recruitment of endogenous enzymes, RNase H or RISC, limiting the chemical architecture of oligonucleotide drugs. LÄS MER
22. Studies on nucleic acids chemistry
Sammanfattning : This thesis is divided into three parts: Part 1: Synthesis and conformational analysis of cyclic RNAs, and comparison with lariat RNAs modelling the lariat formed during processing of Group II and Nuclear pre-mRNA. Synthesis of a hexameric lariat RNA model with a tetranucleotidyl "2' → 5' loop" and a dinucleotidyl "3'-tail" has been accomplished. LÄS MER