Sökning: "RGD peptide"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden RGD peptide.

  1. 1. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

    Författare :Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. LÄS MER

  3. 2. Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose

    Författare :Helen Fink; Göteborgs universitet; []
    Nyckelord :bacterial cellulose; endothelial cells; thrombogenicity; xyloglucan; contact activation; imaging of coagulation; vascular grafts; RGD; cell adhesion; bioreactor; xyloglucan;

    Sammanfattning : Cardiovascular diseases are still the number one cause of death or invalidity in the western world today. Atherosclerotic plaques and restenosis can result in severe occlusions of peripheral and coronary arteries. Treatment depends on the severity of the disease and includes drug therapy and bypass surgery. LÄS MER

  4. 3. Biomolecule Functionalization of Diamond Surfaces for Implant Applications - A Theoretical Study

    Författare :Yuan Tian; Karin Larsson; Lars Ojamäe; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Diamond; Biomolecules; Functionalization; VEGF; BMP2; Fibronectin; Chitosan; Heparin; RGD peptide; Angiopoietin; Theoretical; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

    Sammanfattning : Diamond is a promising material with unique chemical properties. In this thesis, nano-scale diamond quantum size effects were investigated using several chemical property indicators. LÄS MER

  5. 4. Structural and synthetic studies on peptide analogues to the cell adhesive sequence RGD (Arg-Gly-Asp)

    Författare :Henrik Mickos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Fibronectin is a cell adhesive protein with many different biological functions. The cell adhesive properties have been ascribed on a small polypeptide sequence RGD (Arginine-Glycine-Aspartic acid) also found in other cell adhesive proteins. LÄS MER

  7. 5. The development of synthetic gene delivery systems

    Författare :Lars J Brandén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gene transfer; synthetic vector; gene therapy; Bioplex; PNA; NLS;

    Sammanfattning : This thesis describes a new platform technology. The technique is referred to as Bioplex (biological complex) in analogy with the nomenclature for other transfection reagents, since we attach biological functions to a nucleic acid complex via sequence-specific hybridisation. LÄS MER