Sökning: "REGULATORY NETWORK"

Visar resultat 1 - 5 av 187 avhandlingar innehållade orden REGULATORY NETWORK.

1. 1. Exploring the Boundaries of Gene Regulatory Network Inference

   Författare :Andreas Tjärnberg; Erik Sonnhammer; Richard Bonneau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GRN; gene regulatory network; network inference; signal to noise ratio; model selection; variable selection; data properties; reverse engineering; ordinary differential equations; gene networks; linear regression; lasso; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : To understand how the components of a complex system like the biological cell interact and regulate each other, we need to collect data for how the components respond to system perturbations. Such data can then be used to solve the inverse problem of inferring a network that describes how the pieces influence each other. LÄS MER

3. 2. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments

   Författare :Torbjörn E. M. Nordling; Elling W Jacobsen; Rolf Findeisen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

   Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER

4. 3. Towards Reliable Gene Regulatory Network Inference

   Författare :Daniel Morgan; Erik Sonnhammer; John Quackenbush; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GRN; network inference; biological systems; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Phenotypic traits are now known to stem from the interplay between genetic variables across many if not every level of biology. The field of gene regulatory network (GRN) inference is concerned with understanding the regulatory interactions between genes in a cell, in order to build a model that captures the behaviour of the system. LÄS MER

5. 4. Electricity Distribution Network Planning Considering Distributed Generation

   Författare :Yalin Huang; Lennart Söder; Karin Alvehag; Peiyuan Chen; KTH; []
   Nyckelord :Electricity distribution network; network planning; distributed generation; Electrical Engineering; Elektro- och systemteknik;

   Sammanfattning : One of EU’s actions against climate change is to meet 20% of our energy needs from renewable resources. Given that the renewable resources are becoming more economical to extract electricity from, this will result in that more and more distributed generation (DG) will be connected to power distribution. LÄS MER

7. 5. In silico modelling for refining gene regulatory network inference

   Författare :Thomas Hillerton; Erik L. L. Sonnhammer; Richard Bonneau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Gene regulatory networks; simulation; benchmarking; method development; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

   Sammanfattning : Gene regulation is at the centre of all cellular functions, regulating the cell's healthy and pathological responses. The interconnected system of regulatory interactions is known as the gene regulatory network (GRN), where genes influence each other to maintain strict and robust control. LÄS MER