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Visar resultat 1 - 5 av 33 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3

    Författare :Lubna Yasmin; Bengt Hallberg; Joan Olson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExoS; ADP-ribosylation; 14-3-3 protein; Pseudomonas aeruginosa; Small GTPases; RAS; RAP; Pathology; Patologi;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic pathogen that is a serious problem for immuno-compromised patients. Toxins such as exoenzyme (Exo) S, ExoT, ExoY and ExoU are secreted and translocated from the bacteria into the eukaryotic cell via the bacterial encoded type III secretion system. LÄS MER

  3. 2. Host-Pathogen Interactions in Pseudomonas aeruginosa Invasive and Respiratory Tract Infection

    Författare :Magnus Paulsson; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseudomonas aeruginosa; vitronectin; Respiratory tract infections; Innate Immunity; outer membrane vesicles; outer membrane proteins; beta-lactamase; ciprofloxacin; combination treatment; bacteraemia; Complement escape;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic bacterium that causes debilitating infections when the immune defence is compromised. It possesses an arsenal of virulence traits to colonize most compartments of the body and is often highly resistant against commonly used antimicrobial drugs. LÄS MER

  4. 3. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa

    Författare :Shah Jalal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :quinolone resistance; P. aeruginosa; PCR; DNA sequencing; mutation; NIRCA; RESA; multidrug efflux; cystic fibrosis;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic nosocomial pathogen. In compromised human, it can cause infections in urinary tract, wound and respiratory tract such as pneumonia and progressive lung diseases. LÄS MER

  5. 4. Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System

    Författare :Caroline E. Zetterström; Mikael Elofsson; Samuel I. Miller; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER

  7. 5. Bacteria-responsive materials for drug delivery

    Författare :Marina Craig; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; triggered release; multilayer; controlled release; Layer-by-layer; nanofilm; infection; enzymatic degradation;

    Sammanfattning : The number of diabetics, obese individuals and other patients carrying other lifestyle diseasesis increasing worldwide. At the same time the population is ageing. These patients all sufferfrom poor blood circulation, which often gives rise to non-healing, or chronic, wounds. Thus,the number of chronic wounds is also increasing at a fast pace. LÄS MER