Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations

    Författare :Per Uhlén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; Ca2 signalling; Ca2 oscillation; InsP3; InsP3 receptor; Na; K-ATPase; ouabain; physical interaction; FRET; spectral analysis; confocal microscopy;

    Sammanfattning : Signal transduction via ion fluxes is of vital importance for all mammalian cells. Cells can exploit ion regulatory mechanisms to generate and transmit intracellular signals. Improvements in digital microscopic imaging technology have made it possible to explore micro-environments and complex intracellular machineries. LÄS MER

  3. 2. Host-parasite interactions in the dissemination of Toxoplasma gondii

    Författare :Sachie Kanatani; Antonio Barragan; Per Uhlén; Isabelle Tardieux; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apicomplexa; dendritic cells; microglia; cell migration; 14-3-3 proteins; GABAergic signaling; voltage-dependent calcium channel; host-parasite interaction; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Toxoplasma gondii is an obligate intracellular parasite that infects virtually all warm-blooded organisms. Systemic dissemination of T. gondii in the organism can cause life-threatening infection that manifests as Toxoplasma encephalitis in immune-compromised patients. LÄS MER

  4. 3. The Frequency of the Frequency : On Hydropower and Grid Frequency Control

    Författare :Linn Saarinen; Urban Lundin; Per Norrlund; Bengt Carlsson; Kjetil Uhlen; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; hydropower; frequency control; governors; power system stability; inertia; primary control; Engineering Science with specialization in Science of Electricity; Teknisk fysik med inriktning mot elektricitetslära;

    Sammanfattning : Variations in the electricity consumption and production connected to the power system have to be balanced by active control. Hydropower is the most important balancing resource in the Nordic system, and will become even more important as the share of variable renewable energy sources increases. LÄS MER

  5. 4. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

    Författare :Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

    Sammanfattning : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. LÄS MER