Sökning: "Parkinson s Disease"

Visar resultat 31 - 35 av 55 avhandlingar innehållade orden Parkinson s Disease.

  1. 31. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

    Författare :Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

    Sammanfattning : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. LÄS MER

  3. 32. Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease

    Författare :Torun Malmlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other treatments, while long term treatment is complicated by the gradual emergence of troublesome motor complications i.e. LÄS MER

  4. 33. Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease

    Författare :Ruben Isacson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dopamine is fundamental in human behavior for movement, cognition and reward. A dysfunctional dopamine system is implicated in several neurological and psychiatric disorders such as Parkinson s disease and schizophrenia. Dopamine mediates its effects through five receptors. LÄS MER

  5. 34. The non-human primate as a model of human parkinsonism

    Författare :Alison McCormack; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra; aging; neuromelanin; MPTP; alpha-synuclein; levodopa; dyskinesia; methamphetamine;

    Sammanfattning : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. LÄS MER

  7. 35. Generation of dopamine neurons in vivo and from embryonic stem cells in vitro

    Författare :Stina Friling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mesencephalic dopamine (mesDA) neurons degenerate in patients with Parkinson s disease. In order to develop new treatment strategies for rescuing or replacing degenerating mesDA neurons, an improved understanding of the development and survival of these neurons in the normal brain is required. LÄS MER