Sökning: "Parkinson s Disease"

Visar resultat 36 - 40 av 55 avhandlingar innehållade orden Parkinson s Disease.

1. 36. Studies on caspase signaling in microglia

   Författare :Johanna Rodhe; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. LÄS MER

3. 37. Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome

   Författare :Valentina Siino; Institutionen för immunteknologi; []
   Nyckelord :Phosphoproteomics; mass spectrometry; brain disorders; neurobiology; phosphorylation;

   Sammanfattning : Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. LÄS MER

4. 38. Transcription factor control in neuronal maintenance and survival

   Författare :Banafsheh Kadkhodaei; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons is evident in Parkinson s disease, the most frequent neurodegenerative movement disorder. LÄS MER

5. 39. Characterization of brn1.2 and corticotropin-releasing hormone genes in zebrafish

   Författare :Gayathri Chandrasekar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The zebrafish (Danio rerio), a tropical fresh water fish originally found in the rivers of India and Bangladesh has become a popular vertebrate model system over the last decade. The rapid sequencing of the zebrafish genome together with the latest advances in forward and reverse genetics has made this model organism more fascinating as it can be used to decipher the genetic mechanisms involved in the vertebrate development. LÄS MER

7. 40. Regional control of cell fate determination and neurogenesis in the developing CNS

   Författare :Ulrika Marklund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The development of a functional central nervous system relies on the generation of distinct neuronal subtypes in a spatially and temporally defined order. The spatial organisation is achieved at early developmental time points when neural progenitor cells encounter fields of secreted morphogenic signalling molecules along the anterioposterior and dorsoventral axes of the embryo. LÄS MER